生物
趋化性
趋化因子受体
趋化因子
受体
细胞生物学
信号转导
CCL7型
单核细胞
CXCL2型
CX3CL1型
G蛋白偶联受体
细胞表面受体
炎症
CCR2型
作者
Silvano Sozzani,Massimo Locati,Dan Zhou,Monica Rieppi,Walter Luini,Giuseppe Lamorte,Giancario Bianchi,Nadia Polentarutti,Paola Allavena,Alberto Mantovani
摘要
Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of C-C chemokines, monocyte chemotactic protein-1 (MCP-1), MCP-2, and MCP-3, in particular, encompasses, in addition to monocytes, other leukocyte populations. Evidence is presented that MCP-1, MCP-2, and MCP-3 are active on natural killer cells. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies.
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