大脑
生物
神经节隆起
纹状体
基底神经节
同源盒
基底前脑
腹侧苍白球
解剖
前脑
腹侧纹状体
神经科学
大脑皮层
丘脑
胆碱能的
苍白球
中枢神经系统
多巴胺
遗传学
转录因子
基因
作者
Lori Sussel,Óscar Marín,Shioko Kimura,John L.R. Rubenstein
出处
期刊:Development
[The Company of Biologists]
日期:1999-08-01
卷期号:126 (15): 3359-3370
被引量:857
标识
DOI:10.1242/dev.126.15.3359
摘要
Abstract The telencephalon is organized into distinct longitudinal domains: the cerebral cortex and the basal ganglia. The basal ganglia primarily consists of a dorsal region (striatum) and a ventral region (pallidum). Within the telencephalon, the anlage of the pallidum expresses the Nkx2.1 homeobox gene. A mouse deficient in Nkx2.1 function does not form pallidal structures, lacks basal forebrain TrkA-positive neurons (probable cholinergic neurons) and has reduced numbers of cortical cells expressing GABA, DLX2 and calbindin that migrate from the pallidum through the striatum and into the cortex. We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage.
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