骨骼肌
内分泌学
内科学
鸟苷
克隆(Java方法)
基因
生物
胰岛素抵抗
糖尿病
医学
遗传学
作者
Christine Reynet,C. Ronald Kahn
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1993-11-26
卷期号:262 (5138): 1441-1444
被引量:301
标识
DOI:10.1126/science.8248782
摘要
To identify the gene or genes associated with insulin resistance in Type II (non-insulin-dependent) diabetes mellitus, subtraction libraries were prepared from skeletal muscle of normal and diabetic humans and screened with subtracted probes. Only one clone out of 4000 was selectively overexpressed in Type II diabetic muscle as compared to muscle of non-diabetic or Type I diabetic individuals. This clone encoded a new 29-kilodalton member of the Ras-guanosine triphosphatase superfamily and was termed Rad (Ras associated with diabetes). Messenger ribonucleic acid of Rad was expressed primarily in skeletal and cardiac muscle and was increased an average of 8.6-fold in the muscle of Type II diabetics as compared to normal individuals.
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