Thieme Chemistry Journal Awardees - Where are They Now? Synthesis of p-Phenylene Ethynylene Based Macrocycles and Bimacrocycle through Formation of the Imine Bond

This paper describes the synthesis of three monornacrocycles and one bimacrocycle from two p-phenylene ethynylene frameworks. For two of the monomacrocycles, the two frameworks were linked by an amide unit and the macrocyclization involved the intramolecular formation of one imine bond. For another monomacrocycle and the bimacrocycle, the frameworks contained two and three amino or aldehyde units, respectively, and the macrocyclization involved the intermolecular formation of two and three imine bonds.