葡萄孢霉素
神经保护
原肌球蛋白受体激酶B
蛋白激酶B
LY294002型
海马结构
细胞毒性
化学
药理学
细胞生物学
信号转导
细胞凋亡
生物
神经营养因子
生物化学
神经科学
受体
蛋白激酶C
体外
作者
Jianrong Yang,Teng-Teng Ren,Rongfeng Lan,Xiao‐Yan Qin
出处
期刊:IBRO Reports
[Elsevier]
日期:2020-04-19
卷期号:8: 115-121
被引量:16
标识
DOI:10.1016/j.ibror.2020.04.002
摘要
Tea polyphenols (TP) are the major ingredients in tea beverages that display health-benefits including anti-oxidation, anti-inflammation, anti-aging, attenuating blood pressure and deflating. In this study, we investigated the neuroprotective effects of TP to attenuate staurosporine (STS)-induced cytotoxicity. Rat hippocampal neurons were isolated, cultured and incubated with STS to induce neurite collapse and apoptosis, however, the medication of TP eliminated these adverse effects and maintained the morphology of neurons. STS decreased the expression of pro-BDNF, downregulated the TrkB/Akt/Bcl-2 signaling axis and promoted the activation of Erk1/2 and caspase-3. In contrast, TP rescued the expression of pro-BDNF and antagonistically restored the biochemistry of aforementioned signaling effectors. Consistently, the activity of TP can be attenuated by the inhibition of TrkB or Akt by small chemicals K252a and LY294002. Therefore, BDNF-TrkB and Akt signaling axis is essential for TP-mediated neuroprotective effects. In summary, TP showed beneficial effects to protect neurons from exogenous insults such as STS-induced neural cytotoxicity and cell death.
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