Cypa
生物
亲环素A
肽基脯氨酰异构酶
亲环素
细胞生物学
热休克蛋白
伴侣(临床)
脯氨酸异构酶
蛋白质折叠
热休克蛋白90
热休克蛋白70
顺反异构体
异构酶
生物化学
分子生物学
针脚1
酶
基因
病理
医学
作者
Cristina Daneri-Becerra,Brenda Valeiras,Luciana I. Gallo,Mariana Lagadari,Mario D. Galigniana
摘要
ABSTRACT Cyclophilin A (CyPA, also known as PPIA) is an abundant and ubiquitously expressed protein belonging to the immunophilin family, which has intrinsic peptidyl-prolyl-(cis/trans)-isomerase enzymatic activity. CyPA mediates immunosuppressive action of the cyclic undecapeptide cyclosporine A and is also involved in multiple cellular processes, such as protein folding, intracellular trafficking, signal transduction and transcriptional regulation. CyPA is abundantly expressed in cancer cells, and, owing to its chaperone nature, its expression is induced upon the onset of stress. In this study, we demonstrated that a significant pool of this immunophilin is primarily an intramitochondrial factor that migrates to the nucleus when cells are stimulated with stressors. CyPA shows anti-apoptotic action per se and the capability of forming ternary complexes with cytochrome c and the small acidic co-chaperone p23, the latter interaction being independent of the usual association of p23 with the heat-shock protein of 90 kDa, Hsp90. These CyPA•p23 complexes enhance the anti-apoptotic response of the cell, suggesting that both proteins form a functional unit, the high level of expression of which plays a significant role in cell survival.
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