One‐potandtwo‐potmethods for chalcone derived pyrimidines synthesis and applications

Abstract Chalcone‐derived pyrimidine is a well‐known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio‐isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono‐pyrimidine, bis‐pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one‐pot and two‐pot methods. The one‐pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two‐pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.