Distributions in CEA doubling time differ in patients with recurrent colorectal carcinomas.

癌胚抗原 医学 结直肠癌 直肠 内科学 胃肠病学 转移 淋巴结转移 淋巴结 肿瘤科 癌症
作者
Manabu Yamamoto,Yoshihiko Maehara,Yoshihisa Sakaguchi,Hiroyuki Mine,Takeharu Yamanaka,Daisuke Korenaga,Takeshi Okamura
出处
期刊:PubMed 卷期号:51 (55): 147-51 被引量:15
链接
标识
摘要

Serum carcinoembryonic antigen (CEA) is often measured during follow-up of patients surgically treated for colorectal cancer. We determined characteristic findings in serum CEA concentrations or CEA doubling time (DT) depending on the different tumor distributions in colorectal cancer patients.Serum CEA levels were measured monthly until the patients expired in 32 colorectal cancers after operations. CEA DT was based on semilogarithmic plots of time courses of CEA concentrations.In cases who were preoperatively CEA positive, the maximum serum CEA levels for proximal colon, distal colon and rectal cancers were 384.8+/-586.1 ng/mL, 1395.7+/-1954.6 ng/mL and 1343.4+/-1478.3 ng/mL, respectively. The maximum serum CEA level in cases of the proximal colon in preoperative CEA positive patients was lower than that in cases of distal colon or rectum. The average CEA DT on the proximal colon, distal colon and rectal cancers was 71.62+/-43.77 days, 31.07+/-15.98 days and 73.97+/-36.66 days, respectively. The CEA DT with distal colon cancers was also significantly shorter than that with proximal colon or rectal cancers (p<0.05, p<0.02). The CEA DT for lung metastasis was significantly longer than that for liver metastasis, locally or lymph node metastasis or multiple metastases (p<0.02, p<0.02, p<0.001).CEA DT serves to predict life expectancy for patients with recurrent colorectal cancers with different tumor distributions. We propose that precise measurements of serum CEA are needed so as not to overlook recurrent tumors. Detailed follow-up after operations is necessary for such patients, that CEA DT was noted in case of distal colon cancers.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
能干冰露完成签到,获得积分10
刚刚
牛奶拌可乐完成签到 ,获得积分10
2秒前
量子星尘发布了新的文献求助30
2秒前
周小鱼完成签到 ,获得积分10
6秒前
11秒前
19秒前
老张完成签到,获得积分10
25秒前
27秒前
zhugao完成签到,获得积分10
29秒前
32秒前
南风知我意完成签到,获得积分10
35秒前
朴实寻琴完成签到 ,获得积分10
35秒前
可可可爱完成签到 ,获得积分10
38秒前
lsy完成签到,获得积分10
42秒前
量子星尘发布了新的文献求助10
45秒前
46秒前
46秒前
hwen1998完成签到 ,获得积分10
49秒前
50秒前
51秒前
wwb发布了新的文献求助10
54秒前
55秒前
57秒前
LHT完成签到,获得积分10
58秒前
落寞凌波发布了新的文献求助10
1分钟前
桐桐应助幸福的杨小夕采纳,获得10
1分钟前
韩麒嘉完成签到 ,获得积分10
1分钟前
聪慧的凝海完成签到 ,获得积分0
1分钟前
1分钟前
wwb发布了新的文献求助10
1分钟前
phil完成签到 ,获得积分10
1分钟前
1分钟前
高高菠萝完成签到 ,获得积分10
1分钟前
滴滴滴完成签到 ,获得积分10
1分钟前
yangsi完成签到 ,获得积分10
1分钟前
量子星尘发布了新的文献求助10
1分钟前
1分钟前
酷炫葵阴发布了新的文献求助10
1分钟前
ORANGE完成签到,获得积分10
1分钟前
思源应助松松采纳,获得20
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038029
求助须知:如何正确求助?哪些是违规求助? 3575740
关于积分的说明 11373751
捐赠科研通 3305559
什么是DOI,文献DOI怎么找? 1819224
邀请新用户注册赠送积分活动 892652
科研通“疑难数据库(出版商)”最低求助积分说明 815022