Comparison of propofol vs. remimazolam on emergence profiles after general anesthesia: A randomized clinical trial

Pacu公司 异丙酚 医学 麻醉 氟马西尼 脑电双频指数 镇静 瑞芬太尼 随机对照试验 置信区间 外科 苯二氮卓 内科学 受体
作者
Eun Jung Oh,Yoon Joo Chung,Jong‐Hwan Lee,Eun Jin Kwon,Eun Ah Choi,Young Keun On,Jeong Jin Min
出处
期刊:Journal of Clinical Anesthesia [Elsevier BV]
卷期号:90: 111223-111223 被引量:21
标识
DOI:10.1016/j.jclinane.2023.111223
摘要

The emergence profiles in patients undergoing total intravenous anesthesia with either propofol or remimazolam with flumazenil reversal were compared. A prospective, double-blind, randomized trial. An operating room and a post-anesthesia care unit (PACU). Adult patients (n = 100) having American Society of Anesthesiologists (ASA) physical status of I-III undergoing general anesthesia were enrolled and randomly assigned to the propofol or the remimazolam group. The propofol group received target-controlled infusion of propofol, and the remimazolam group received continuous infusion of remimazolam. Continuous infusion of remifentanil was used in both groups. For emergence, flumazenil was used in increments of 0.2 mg in the remimazolam group. The primary outcome was the time required for the patient to obey verbal commands. The secondary outcomes included the time to bispectral index (BIS) over 80, the time to laryngeal mask airway (LMA) removal, the Richmond Agitation-Sedation Scale (RASS) scores in the PACU, and adverse events throughout the study period. The time taken to obey verbal commands was significantly longer in the propofol group than the remimazolam group (14 [9, 19]) vs. 5 [3, 7]) minutes, P < 0.001; median difference -9, 95% confidence interval -11 to -6). The times to BIS over 80 and to LMA removal were also significantly longer in the propofol group. In addition, the RASS score upon arrival to the PACU differed significantly between the two groups (P = 0.006). Re-sedation in the PACU was observed in 11 (22%) of the patients in the remimazolam group. Remimazolam-based total intravenous anesthesia with flumazenil reversal may be effective in reducing emergence time, but a significant incidence of re-sedation was observed in the PACU. Further studies are needed to determine adequate dose and timing of routine flumazenil use and minimize the risk of re-sedation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
默默的彩虹完成签到,获得积分10
1秒前
4秒前
4秒前
顾矜应助年轻半雪采纳,获得10
4秒前
Ing发布了新的文献求助10
4秒前
5秒前
上官若男应助曾经晓亦采纳,获得10
8秒前
Jasper应助翁雁丝采纳,获得10
8秒前
菠萝菠萝发布了新的文献求助10
9秒前
10秒前
简单发布了新的文献求助10
10秒前
DD完成签到,获得积分20
11秒前
爱自己就好完成签到,获得积分10
12秒前
可靠的雪碧完成签到,获得积分10
12秒前
西瓜汽水发布了新的文献求助10
14秒前
16秒前
无花果应助稀罕你采纳,获得10
16秒前
16秒前
16秒前
17秒前
18秒前
19秒前
nnnn发布了新的文献求助30
20秒前
20秒前
林机一动发布了新的文献求助10
22秒前
niki发布了新的文献求助10
22秒前
隐形曼青应助翁雁丝采纳,获得10
22秒前
23秒前
sbw发布了新的文献求助10
24秒前
852应助北彧采纳,获得10
25秒前
Ava应助水天采纳,获得10
25秒前
paulmichael发布了新的文献求助10
26秒前
26秒前
26秒前
bird完成签到,获得积分10
27秒前
28秒前
zfm发布了新的文献求助10
29秒前
29秒前
31秒前
结实伯云完成签到,获得积分10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975722
求助须知:如何正确求助?哪些是违规求助? 3520056
关于积分的说明 11200719
捐赠科研通 3256455
什么是DOI,文献DOI怎么找? 1798271
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806390