免疫学
血管炎
免疫系统
医学
抗体
表型
疾病
外围设备
生物
病理
内科学
生物化学
基因
作者
Kotaro Matsumoto,Katsuya Suzuki,Hidekata Yasuoka,Junichi Hirahashi,Hiroto Yoshida,Mayu Magi,Mariko Noguchi-Sasaki,Yuko Kaneko,Tsutomu Takeuchi
标识
DOI:10.1016/j.autrev.2023.103271
摘要
Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a necrotizing multiorgan autoimmune disease that affects small- to medium-sized blood vessels. Despite the improvements in treatments, half of the patients with AAV still experience disease relapses. In this review, we focus on peripheral leukocyte properties and phenotypes in patients with AAV. In particular, we explore longitudinal changes in circulating immune cell phenotypes during the active phase of the disease and treatment. The numbers and phenotypes of leukocytes in peripheral blood were differs between AAV and healthy controls, AAV in active versus inactive phase, AAV in treatment responders versus non-responders, and AAV with and without severe infection. Therefore, biomarkers detected in peripheral blood immune cells may be useful for longitudinal monitoring of disease activity in AAV.
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