Advances in the gut microbiome and mood disorders

情绪障碍 微生物群 双相情感障碍 心情 重性抑郁障碍 肠道菌群 医学 临床试验 精神科 随机对照试验 心理干预 临床心理学 心理学 生物信息学 内科学 免疫学 生物 焦虑
作者
Sabrina Mörkl,Mary I. Butler,Sonja Lackner
出处
期刊:Current Opinion in Psychiatry [Ovid Technologies (Wolters Kluwer)]
卷期号:36 (1): 1-7 被引量:11
标识
DOI:10.1097/yco.0000000000000829
摘要

Purpose of review The gut microbiome is in constant bidirectional communication with the brain through the microbiota-gut-brain-axis. Mood disorders are among the most common psychiatric disorders and include major depressive disorder and bipolar disorder. The gut microbiome is altered in individuals with mood disorders and has a role in its inflammatory pathophysiology. In this article, we performed a narrative review of clinical studies, randomized controlled trials and meta-analyses addressing advances in gut microbiome research in mood disorders and included articles that were published between 2021 and 2022. Recent findings Studies highlight transdiagnostic alterations of microbiota in mood disorders, with reductions of butyrate-producing bacteria. Participants with major depressive disorder showed altered beta-diversity, while participants with bipolar disorder showed reduced alpha-diversity. Both disorders exhibit alterations in the metabolome. Early pilot studies addressed the possibility of using the gut microbiome for the prediction of treatment response and the blood microbiome for the diagnosis of psychiatric disorders. Findings from clinical trials support the use of probiotics as an add-on therapy for major depressive disorder. The second published case report in the literature reported a favourable outcome of a patient with bipolar disorder after faecal microbiota transplantation. Summary Gut microbiome modulations allow new treatment strategies including the use of psychobiotics for the treatment and prevention of mood disorders. Well designed clinical trials aiming for personalized medicine are needed to investigate the efficacy and safety of psychobiotic interventions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
雪白起眸发布了新的文献求助10
2秒前
lulu发布了新的文献求助10
2秒前
舟逝发布了新的文献求助10
3秒前
yearluren完成签到,获得积分10
4秒前
刘慧12发布了新的文献求助10
5秒前
Jasper应助solar@2030采纳,获得10
5秒前
John_sdu完成签到,获得积分10
5秒前
养恩应助yuhuihui采纳,获得10
5秒前
韩十四发布了新的文献求助10
6秒前
火星上的菲鹰应助aaaa采纳,获得10
6秒前
充电宝应助王哪跑12采纳,获得10
8秒前
外向的跳跳糖完成签到,获得积分10
9秒前
vicky完成签到,获得积分10
9秒前
乐观的小鸡完成签到 ,获得积分10
10秒前
ludens完成签到,获得积分10
11秒前
收费完成签到,获得积分20
12秒前
13秒前
彦子完成签到 ,获得积分10
14秒前
小蘑菇应助ssy采纳,获得10
14秒前
14秒前
亚亚吖完成签到 ,获得积分10
15秒前
15秒前
牧子完成签到,获得积分10
17秒前
17秒前
18秒前
Nofear发布了新的文献求助10
18秒前
solar@2030发布了新的文献求助10
19秒前
王哪跑12发布了新的文献求助10
20秒前
21秒前
科研通AI2S应助雪白起眸采纳,获得10
21秒前
牛牛完成签到,获得积分10
22秒前
3MB完成签到 ,获得积分10
22秒前
23秒前
23秒前
飞快的鱼发布了新的文献求助10
24秒前
南南完成签到,获得积分10
24秒前
飘逸怜菡完成签到,获得积分10
24秒前
沙洲发布了新的文献求助10
25秒前
鲸鱼完成签到,获得积分10
25秒前
高分求助中
Comparative Anatomy of the Vertebrates 9th 3000
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3572057
求助须知:如何正确求助?哪些是违规求助? 3142380
关于积分的说明 9447329
捐赠科研通 2843772
什么是DOI,文献DOI怎么找? 1563095
邀请新用户注册赠送积分活动 731568
科研通“疑难数据库(出版商)”最低求助积分说明 718570