电子线路
神经科学
生物
内科学
心理学
医学
工程类
电气工程
作者
Kyu Sik Kim,Joon Seok Park,Eun‐Sang Hwang,Min-Jung Park,Hwa Yun Shin,Young Hee Lee,Kyung Min Kim,Laurent Gautron,Elizabeth Godschall,B Portillo,Kyle Grose,Sang-Ho Jung,So Lin Baek,Young Hyun Yun,Doyeon Lee,Eunseong Kim,Jason Ajwani,Seong Ho Yoo,Ali D. Güler,Kevin W. Williams,Hyung Jin Choi
出处
期刊：Science
[American Association for the Advancement of Science (AAAS)]
日期：2024-06-27
卷期号：385 (6707): 438-446
被引量：10
标识
DOI：10.1126/science.adj2537
摘要
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMH
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