克里唑蒂尼
CYP3A4型
药代动力学
药理学
化学
代谢物
微粒体
体内
新陈代谢
生物
内科学
生物化学
酶
医学
细胞色素P450
遗传学
胸腔积液
恶性胸腔积液
作者
Jing Wang,Xiaoyu Xu,Xinyue Li,Jian-chao Luo,Zhe-yan Zhang,Jing Chen,Jianping Cai,Li‐Kang Zhang,Jian-chang Qian
标识
DOI:10.1016/j.taap.2024.117016
摘要
To elucidate the impact of CYP3A4 activity inhibition and genetic polymorphism on the metabolism of crizotinib. Enzymatic incubation systems for crizotinib were established, and Sprague-Dawley rats were utilized for in vivo experiments. Analytes were quantified using LC-MS/MS. Upon screening 122 drugs and natural compounds, proanthocyanidins emerged as inhibitor of crizotinib metabolism, exhibiting a relative inhibition rate of 93.7%. The IC
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