阻塞性睡眠呼吸暂停
医学
荟萃分析
检查表
科克伦图书馆
内科学
子群分析
出版偏见
队列研究
心理学
认知心理学
作者
Stefano Zoroddu,Biagio Di Lorenzo,Salvatore Sotgia,Panagiotis Paliogiannis,Arduino A. Mangoni,Alessandro G. Fois,Pietro Pirina,Ciriaco Carru,Angelo Zinellu
标识
DOI:10.1016/j.sleep.2024.06.018
摘要
This systematic review and meta-analysis investigates the relationship between haemoglobin (Hb) concentrations and obstructive sleep apnea syndrome (OSAS). Following PRISMA guidelines, we searched PubMed, EMBASE, and Cochrane Library from inception to March 8, 2024. Eligible studies included cross-sectional, cohort, and case-control designs comparing Hb concentrations in OSAS patients and healthy controls. Two reviewers independently screened records and extracted data. The risk of bias was assessed using the Joanna Briggs Institute checklist. A total of 27 studies involving 6499 OSAS subjects and 5199 controls were included. Hb concentrations were significantly higher in OSAS patients compared to controls (SMD: 0.28; 95 % CI: 0.18 to 0.39; I2 = 84.4 %). Subgroup analysis by OSAS severity showed that severe OSAS patients had higher Hb concentrations than those with mild/moderate OSAS. Sensitivity analyses confirmed the robustness of the findings. However, 7 studies reported opposite results, indicating possible regional or methodological differences. Hb concentrations are elevated in OSAS patients, with higher levels observed in severe cases. The significant heterogeneity and the predominance of studies from Turkey highlight the need for further research in diverse populations. Limitations include potential publication bias and variability in study designs.
科研通智能强力驱动
Strongly Powered by AbleSci AI