Antithrombin Deficiency during Venoarterial Extracorporeal Membrane Oxygenation: Extremely Common, but Does It Matter?

Editorial| June 2024 Antithrombin Deficiency during Venoarterial Extracorporeal Membrane Oxygenation: Extremely Common, but Does It Matter? Michael Mazzeffi, M.D., M.P.H., F.A.H.A.; Michael Mazzeffi, M.D., M.P.H., F.A.H.A. 1University of Virginia School of Medicine, Department of Anesthesiology, Charlottesville, Virginia. Search for other works by this author on: This Site PubMed Google Scholar Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M. Jerrold H. Levy, M.D., F.A.H.A., F.C.C.M. 2Departments of Anesthesiology, Critical Care, and Surgery Duke University School of Medicine, Durham, North Carolina. https://orcid.org/0000-0003-3766-4962 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information This editorial accompanies the article on p. 1153. Accepted for publication February 12, 2024. Address correspondence to Dr. Levy: Anesthesiology June 2024, Vol. 140, 1065–1067. https://doi.org/10.1097/ALN.0000000000004948 Connected Content Article: Antithrombin Levels and Heparin Responsiveness during Venoarterial Extracorporeal Membrane Oxygenation: A Prospective Single-center Cohort Study Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Michael Mazzeffi, Jerrold H. Levy; Antithrombin Deficiency during Venoarterial Extracorporeal Membrane Oxygenation: Extremely Common, but Does It Matter?. Anesthesiology 2024; 140:1065–1067 doi: https://doi.org/10.1097/ALN.0000000000004948 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: antithrombin iii deficiency, extracorporeal membrane oxygenation In this issue of Anesthesiology, Mansour et al.1 explore the significance of antithrombin deficiency, defined by a time-weighted average antithrombin activity less than 70%, in adults on venoarterial extracorporeal membrane oxygenation (ECMO). Previous studies of antithrombin deficiency in cardiac surgical patients identified antithrombin activity less than 60%, as being associated with mortality and other complications.2 However, in ECMO patients, there is a relative paucity of data on antithrombin deficiency and its significance. Hence, the study of Mansour et al.1 adds significantly to the existing literature. In their study, Mansour et al.1 analyzed 50 venoarterial ECMO patients (42% postcardiotomy shock) who had antithrombin activity measured serially for 7 days with 11 total measurements per patient. Heparin responsiveness was assessed based on anti-Xa level, daily heparin dose, and a derived heparin sensitivity index, which was calculated by dividing hourly per kilogram heparin dose by anti-Xa level.... You do not currently have access to this content.