Abstract: Ultrasound is an indispensable technology in the biomedical field. With the continuous integration and development of ultrasound medical technology, its potential application value in disease diagnosis and treatment has become increasingly prominent. As the technical core, novel multifunctional ultrasound theranostic agents have been the main focus of research. Here, we summarized various types of multifunctional ultrasound agents, presented their latest applications in important areas, and discussed subsequent research priorities. We hope that with the combination of new technologies, multifunctional ultrasound agents can play a greater role in the diagnosis and treatment of diseases, further promoting the extensive and in-depth development of ultrasound medical technology.