作者
Jiali Yu,Yijian Yan,Shasha Li,Ying Xu,Abhijit Parolia,Syed Rizvi,Yu Wang,Yiwen Zhai,Rongxin Xiao,Li Xiong,Peng Liao,Jiajia Zhou,Karolina Okła,Heng Lin,Xun Lin,Sara Grove,Shuang Wei,Linda Vatan,Jan C.‐C. Hu,Justyna Szumiło,Jan Kotarski,Zachary T. Freeman,Stephanie L. Skala,Max S. Wicha,Kathleen R. Cho,Arul M. Chinnaiyan,Samantha B. Schon,Fei Wen,Ilona Kryczek,Shaomeng Wang,Lieping Chen,Weiping Zou
摘要
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolerance checkpoint. We showed that genetic deficiency of B7-H4 resulted in immune activation and fetal resorption in allogeneic pregnancy models. Analogously, B7-H4 contributed to MPA/DMBA-induced breast cancer progression, accompanied by CD8
吃不饱星球球长
寻道图强
豆子
Ally
鹊起
嗯哼
穆紫
于芋菊
一一
CipherSage
英姑
丰盛的煎饼
Frank
cc
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Akim
爆米花
Luis
所所
酷波er
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