作者
Jiali Yu,Yijian Yan,Shasha Li,Ying Xu,Abhijit Parolia,Syed Rizvi,Yu Wang,Yiwen Zhai,Rongxin Xiao,Li Xiong,Peng Liao,Jiajia Zhou,Karolina Okła,Heng Lin,Xun Lin,Sara Grove,Shuang Wei,Linda Vatan,Jan C.‐C. Hu,Justyna Szumiło,Jan Kotarski,Zachary T. Freeman,Stephanie L. Skala,Max S. Wicha,Kathleen R. Cho,Arul M. Chinnaiyan,Samantha B. Schon,Fei Wen,Ilona Kryczek,Shaomeng Wang,Lieping Chen,Weiping Zou
摘要
Immune tolerance mechanisms are shared in cancer and pregnancy. Through cross-analyzing single-cell RNA-sequencing data from multiple human cancer types and the maternal-fetal interface, we found B7-H4 (VTCN1) is an onco-fetal immune tolerance checkpoint. We showed that genetic deficiency of B7-H4 resulted in immune activation and fetal resorption in allogeneic pregnancy models. Analogously, B7-H4 contributed to MPA/DMBA-induced breast cancer progression, accompanied by CD8
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