挤压
纳米纤维
材料科学
制作
3D生物打印
纳米技术
组织工程
静电纺丝
生物医学工程
复合材料
聚合物
医学
替代医学
病理
作者
Huiquan Wu,Feng Xu,Hang Jin,Mingcheng Xue,Wangzihan Zhang,Jianhui Yang,Junyi Huang,Yuqing Jiang,Bin Qiu,Bin Lin,Qiang Gao,Songyue Chen,Daoheng Sun
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2024-10-19
标识
DOI:10.1021/acsbiomaterials.4c01611
摘要
Three-dimensional (3D) bioprinting technology stands out as a promising tissue manufacturing process to control the geometry precisely with cell-loaded bioinks. However, the isotropic culture environment within the bioink and the lack of topographical cues impede the formation of oriented cardiac tissue. To overcome this limitation, we present a novel method named 3D nanofiber-assisted embedded bioprinting (3D-NFEP) to fabricate cardiac tissue with an oriented morphology. Aligned 3D nanofiber scaffolds were fabricated by divergence electrospinning, which provided structural support for printing of the low-viscosity bioink and structural induction to cardiomyocytes. Cells adhered to the aligned fibers after hydrogel degradation, and a high degree of cell alignment was observed. This technology was also demonstrated as a feasible solution for multilayer cell printing. Therefore, 3D-NFEP was demonstrated as a promising method for bioprinting oriented cardiac tissue with low-viscosity bioink and is expected to be applied for structured and cardiac tissue engineering.
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