硼酸化
铱
催化作用
化学
动力学分辨率
动能
药物化学
立体化学
组合化学
有机化学
对映选择合成
物理
芳基
烷基
量子力学
作者
Maosheng He,Liangjun Xie,Lili Chen,Senmiao Xu
标识
DOI:10.1021/acscatal.4c06245
摘要
Chiral 2,5-disubstituted pyrrolidines are ubiquitous subunits in natural products, bioactive compounds, pharmaceuticals, and chiral catalysts. However, their asymmetric synthesis still presents a formidable challenge. We herein report a rare example of diastereodivergent parallel kinetic resolution of racemic 2-substituted pyrrolidines via C(sp3)–H borylation. A vast array of enantioenriched cis- and trans-2,5-disubstituted pyrrolidines were obtained with high enantioselectivities. The synthetic utility was demonstrated by downstream transformations, including the synthesis of optically active pyrrolidine 197B and cis-pyrrolidine 225H.
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