Bovine Serum Albumin/Polyvinyl Alcohol Double‐Network Hydrogel Containing ϵ‐Polylysine for Antibacterial Performance

Abstract With the discovery and abuse of antibiotics, bacterial resistance has become a key problem in the field of antibacterial materials. Therefore, antibacterial materials that can effectively inhibit bacterial infection are considered to be important biological materials. In this study, a double‐network hydrogel system was designed using bovine serum albumin (BSA) and polyvinyl alcohol (PVA) as the main body. The first network was formed by reducing the disulfide bond on BSA to sulfhydryl group by tris (2‐carboxyethyl) phosphine (TCEP). The second network of PVA was used as the hydrogel to prepare a double‐network hydrogel with good mechanical strength. The introduction of ϵ‐polylysine gives the hydrogel antibacterial activity, which enables it to destroy the cell structure and kill bacteria through electrostatic interaction, and can effectively solve the problem of drug resistance in the field of antibacterial medicine.