Multi-functional dual-layer nanofibrous membrane for prevention of postoperative pancreatic leakage

材料科学 泄漏(经济) 静电纺丝 生物相容性 明胶 止血 生物医学工程 伤口愈合 复合材料 外科 医学 化学 生物化学 聚合物 冶金 经济 宏观经济学
作者
Prayas Chakma Shanto,Md. Abdullah Al Fahad,Hae Il Jung,Myeongki Park,Hye‐Young Kim,Sang Ho Bae,Byong‐Taek Lee
出处
期刊:Biomaterials [Elsevier BV]
卷期号:307: 122508-122508 被引量:3
标识
DOI:10.1016/j.biomaterials.2024.122508
摘要

Postoperative pancreatic leakage due to pancreatitis in patients is a life-threatening surgical complication. The majority of commercial barriers are unable to meet the demands for pancreatic leakage due to poor adhesiveness, toxicity, and inability to degrade. In this study, we fabricated mitomycin-c and thrombin-loaded multifunctional dual-layer nanofibrous membrane with a combination of alginate, PCL, and gelatin to resolve the leakage due to suture line disruption, promote hemostasis, wound healing, and prevent postoperative tissue adhesion. Electrospinning was used to fabricate the dual-layer system. The study results demonstrated that high gelatin and alginate content in the inner layer decreased the fiber diameter and water contact angle, and crosslinking allowed the membrane to be more hydrophilic, making it highly biodegradable, and adhering firmly to the tissue surfaces. The results of in vitro biocompatibility and hemostatic assay revealed that the dual-layer had a higher cell proliferation and showed effective hemostatic properties. Moreover, the in vivo studies and in silico molecular simulation indicated that the dual layer was covered at the wound site, prevented suture disruption and leakage, inhibited hemorrhage, and reduced postoperative tissue adhesion. Finally, the study results proved that dual-layer multifunctional nanofibrous membrane has a promising therapeutic potential in preventing postoperative pancreatic leakage.
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