邻苯二甲酸盐
内分泌系统
生殖毒性
生殖健康
怀孕
生殖系统
内分泌学
激素
二羟基化合物
内分泌干扰物
内科学
生物
医学
生理学
毒性
双酚A
环境卫生
化学
人口
遗传学
有机化学
环氧树脂
作者
Alejandra Martínez-Ibarra,Marco Cerbón,Luis Daniel Martínez-Razo,Miguel Morales-Pacheco,Iván Torre-Villalvazo,Simón Kawa,Mauricio Rodríguez‐Dorantes
标识
DOI:10.1016/j.etap.2024.104391
摘要
Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. In vitro and in vivo studies link DEHP exposure to impaired hypothalamic-pituitary-ovarian s (HPO) axis function, alteration of steroid-hormone levels and dysregulation of their receptors, and changes in uterine morphophysiology. In addition, high urinary DEPH levels have been associated with several reproductive disorders in women, including endometriosis, fibromyoma, fetal growth restriction and pregnancy loss. These data suggest that DEHP may be involved in the pathophysiology of various female reproductive diseases. Therefore, exposure to these compounds should be considered a concern in clinician surveillance practices for women at reproductive age and should be regulated to protect their health and that of their progeny.
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