偏头痛
降钙素基因相关肽
偏头痛治疗
生物信息学
神经科学
慢性偏头痛
医学
重症监护医学
药理学
内科学
受体
神经肽
心理学
生物
作者
Chia‐Chun Chiang,Frank Porreca,Carrie E. Robertson,David W. Dodick
标识
DOI:10.1016/s1474-4422(24)00003-6
摘要
Summary
Migraine is a leading cause of disability worldwide. Despite the recent approval of several calcitonin gene-related peptide-targeted therapies, many people with migraine do not achieve satisfactory headache improvement with currently available therapies and there continues to be an unmet need for effective and tolerable migraine-specific treatments. Exploring additional targets that have compelling evidence for their involvement in modulating migraine pathways is therefore imperative. Potential new therapies for migraine include pathways involved in nociception, regulation of homoeostasis, modulation of vasodilation, and reward circuits. Animal and human studies show that these targets are expressed in regions of the CNS and peripheral nervous system that are involved in pain processing, indicating that these targets might be regarded as promising for the discovery of new migraine therapies. Future studies will require assessment of whether targets are suitable for therapeutic modulation, including assessment of specificity, affinity, solubility, stability, efficacy, and safety.
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