AMPA受体
神经科学
神经传递
离子通道连接受体
致电离效应
兴奋性突触后电位
新加坡元1
长期抑郁
化学
神经药理学
谷氨酸受体
受体
生物
抑制性突触后电位
生物化学
激酶
作者
Mohammad Qneibi,Sosana Bdir,Mohammad Bdair,Samia Ammar Aldwaik,Dana Sandouka,Maram Heeh,Tala Iyad Idais
标识
DOI:10.1016/j.ejmech.2024.116151
摘要
The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.
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