[Effect of acupuncture on pain-emotion related brain regions in patients with cervical spondylosis of cervical type: a fMRI study].

医学 功能磁共振成像 可视模拟标度 颈椎病 针灸科 脑岛 静息状态功能磁共振成像 物理疗法 磁共振成像 麻醉 神经科学 放射科 心理学 病理 替代医学
作者
Wei‐Chih Shen,Bei-Lei Zou,Dandan Li,Yixiang Wang,Huacheng Wang,Ao-Long Yang,Wei Bin-bin,Zhi‐Wei Sun
标识
DOI:10.13703/j.0255-2930.20201022-k0007
摘要

OBJECTIVE To observe the changes of functional connectivity of brain pain-emotion regulation region in patients with cervical spondylosis of cervical type by functional magnetic resonance imaging (fMRI). METHODS Thirty-two subjects were selected. Of them, 16 patients with cervical spondylosis of cervical type were divided into an observation group and 16 healthy subjects into a control group. The patients in the observation group were treated with acupuncture at Tianzhu (BL 10), Jingbailao (EX-HN 15), Jianzhongshu (SI 15) and ashi points for 30 min. The rest-state fMRI data was collected before and after acupuncture in the observation group. The subjects in the control group received no treatment, and the rest-state fMRI data was collected once. The visual analogue scale (VAS) score before and after treatment and the pain catastrophizing scale (PCS) score before treatment in the observation group were recorded. The resting-state brain functional imaging characteristics between the observation group and control group before treatment, between the observation group before and after treatment, were compared. Based on the brain functional connectivity of region of interest (ROI) the changes of functional connectivity in insula and ventral tegmental area (VTA) in emotional regulation brain region were observed, and the correlation between functional connectivity changes and VAS、PCS scores in patients of the observation group was analyzed. RESULTS In the observation group, the VAS score was (1.94±1.12) after the treatment, which was lower than (5.62±1.20) before treatment (P<0.05). The PCS score before treatment was (19.18±8.42) in the observation group. Compared with the control group, the areas with increased functional connectivity with insula in the observation group before acupuncture included bilateral dorsolateral prefrontal lobe and right middle cingulate gyrus, and the areas with increased functional connectivity with VTA included right central posterior gyrus and right insula. In the observation group, the connectivity coefficient of left insula and left dorsolateral prefrontal lobe (r=0.438, P<0.05), the connectivity coefficient of right insula and right dorsolateral prefrontal lobe (r=0.483, P<0.05) were positively associated with the VAS score. In the observation group, the connectivity coefficient between the right insula and the right middle cingulate gyrus (r=-0.560, P<0.05), the connectivity coefficient between the right VTA and the right insula (r=-0.525, P<0.05) were negatively associated with the PCS score. After acupuncture, the areas with decreased functional connectivity with insula included bilateral posterior central gyrus, right anterior central gyrus, middle cingulate gyrus and left corpus callosum, while the bilateral suboccipital gyrus and left cerebellum showed increased functional connectivity with right insula. The areas with decreased functional connectivity with VTA included bilateral dorsomedial prefrontal cortex, left anterior cingulate gyrus, right middle temporal gyrus and left anterior cingulate gyrus. After acupuncture in the observation group, the functional connectivity of left VTA left dorsomedial prefrontal cortex and left anterior cingulate cortex (r=-0.548, P<0.05), the functional connectivity of right VTA-bilateral dorsomedial prefrontal cortex and left anterior cingulate cortex (r=-0.547, P<0.05) were negatively associated with the PCS score. CONCLUSION Pain involves the formation and expression of pain-emotion-cognition. Acupuncture can systematically regulate the brain functional connections between cognitive regions such as dorsal prefrontal lobe and anterior cingulate gyrus and emotional regions such as insula and VTA in patients with cervical spondylosis of cervical type, suggesting that acupuncture has a multi-dimensional and comprehensive regulation effect on pain.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
研友_VZG7GZ应助刻苦的如霜采纳,获得10
刚刚
1秒前
1秒前
2秒前
2秒前
TITIME完成签到,获得积分10
3秒前
chenli900108发布了新的文献求助10
3秒前
随便看看完成签到,获得积分20
3秒前
baibai完成签到,获得积分10
4秒前
天天快乐应助开心的中心采纳,获得10
4秒前
qx发布了新的文献求助10
4秒前
Jasper应助墨菲特采纳,获得10
4秒前
yanyl发布了新的文献求助10
5秒前
和和发布了新的文献求助10
6秒前
6秒前
燚燚完成签到,获得积分20
6秒前
落寞的怀莲完成签到,获得积分10
7秒前
小蜜蜂Joyce完成签到,获得积分10
7秒前
Miyya完成签到 ,获得积分10
7秒前
8秒前
SXYYY完成签到,获得积分10
9秒前
萊以托尔福完成签到,获得积分10
9秒前
记号完成签到,获得积分10
10秒前
antirun完成签到,获得积分10
10秒前
10秒前
10秒前
12秒前
Docsiwen完成签到 ,获得积分10
12秒前
dd完成签到,获得积分10
13秒前
14秒前
鲍文启完成签到 ,获得积分10
15秒前
王小贝发布了新的文献求助10
15秒前
17秒前
开心的中心完成签到,获得积分10
17秒前
lyric应助安居宝采纳,获得10
17秒前
17秒前
18秒前
安静的幻然关注了科研通微信公众号
18秒前
pathetic宣宣完成签到,获得积分20
19秒前
19秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3970062
求助须知:如何正确求助?哪些是违规求助? 3514782
关于积分的说明 11175968
捐赠科研通 3250119
什么是DOI,文献DOI怎么找? 1795198
邀请新用户注册赠送积分活动 875630
科研通“疑难数据库(出版商)”最低求助积分说明 804951