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Visual field defects and myopic macular degeneration in Singapore adults with high myopia

医学 眼科 青光眼 视野 眼压 黄斑变性 绝对偏差 视野丧失 眼底(子宫) 数学 统计
作者
Carla Lança,Chen Hsin Sun,Rachel S. Chong,Yee Ling Wong,Monisha E. Nongpiur,Hla Myint Htoon,Sahil Thakur,Debra Q Y Quek,Ching‐Yu Cheng,Quan V. Hoang,Charumathi Sabanayagam,Seang‐Mei Saw,Kah Hie Wong
出处
期刊:British Journal of Ophthalmology [BMJ]
卷期号:106 (10): 1423-1428 被引量:6
标识
DOI:10.1136/bjophthalmol-2020-318674
摘要

Aims To characterise the association between visual field (VF) defects and myopic macular degeneration (MMD) in highly myopic adults without glaucoma. Methods Participants (n=106; 181 eyes) with high myopia (HM; spherical equivalent ≤−5.0 D or axial length (AL) ≥26 mm), after excluding glaucoma and glaucoma suspects, from the Singapore Epidemiology of Eye Diseases-HM study were included in this cross-sectional study. Humphrey VF (central 24–2 threshold), cup-disc ratio (CDR) and intraocular pressure (IOP) measurements were performed. Mean deviation (MD) and pattern SD (PSD), VF defects (normal or abnormal; p<0.05 in ≥3 non-edge contiguous locations) and pattern (eg, generalised sensitivity loss) were analysed. MMD presence was diagnosed from fundus photographs. Generalised estimating equations were used for analysing factors (MD, PSD, VF defects, CDR and IOP) associated with MMD. Results Mean age was 55.4±9.9 years and 51.9% were women (AL=26.7±1.1 mm). MMD eyes had lower MD (−3.8±2.9 dB vs −1.1±1.4 dB) and higher PSD (2.8±1.7 dB vs 1.7±0.6 dB). A higher percentage of MMD eyes (n=48) had abnormal VF (62.5% vs 28.6%; p<0.001) compared with no MMD (n=133 eyes). VF pattern in MMD eyes was significantly different from eyes without MMD (p=0.001) with greater generalised sensitivity loss (53.3% vs 10.5%) and arcuate defects (16.7% vs 10.5%). In multivariate analyses, MD (OR=1.52) and PSD (OR=1.67) were significantly (p=0.003) associated with MMD, but VF defects were not associated with MMD. Conclusion Highly myopic adults with MMD may have VF loss when compared with highly myopic patients without MMD even in adults without glaucoma.
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