Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease

银屑病 银屑病性关节炎 疾病 医学 遗传倾向 全基因组关联研究 遗传建筑学 生物信息学 生物 遗传学 免疫学 基因 基因型 病理 表型 单核苷酸多态性
作者
Rubén Queiró,Pablo Coto-Segura,Leire González-Lara,Eliécer Coto
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:22 (23): 13004-13004 被引量:9
标识
DOI:10.3390/ijms222313004
摘要

Psoriasis is a multifactorial genetic disease for which the genetic factors explain about 70% of disease susceptibility. Up to 30-40% of psoriasis patients develop psoriatic arthritis (PsA). However, PsA can be considered as a "disease within a disease", since in most cases psoriasis is already present when joint complaints begin. This has made studies that attempt to unravel the genetic basis for both components of psoriatic disease enormously difficult. Psoriatic disease is also accompanied by a high burden of comorbid conditions, mainly of the cardiometabolic type. It is currently unclear whether these comorbidities and psoriatic disease have a shared genetic basis or not. The nuclear factor of kappa light chain enhancer of activated B cells (NF-κB) is a transcription factor that regulates a plethora of genes in response to infection, inflammation, and a wide variety of stimuli on several cell types. This mini-review is focused on recent findings that highlight the importance of this pathway both in the susceptibility and in the determinism of some features of psoriatic disease. We also briefly review the importance of genetic variants of this pathway as biomarkers of pharmacological response. All the above may help to better understand the etiopathogenesis of this complex entity.
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