纳米探针
模态(人机交互)
磁共振成像
材料科学
可视化
脑瘤
放射科
医学
计算机科学
纳米颗粒
病理
纳米技术
人工智能
作者
Chunyan Li,Limin Cao,Yejun Zhang,Peiwei Yi,Mao Wang,Bo Tan,Zongwu Deng,Dongmin Wu,Qiangbin Wang
出处
期刊:Small
[Wiley]
日期:2015-06-08
卷期号:11 (35): 4517-4525
被引量:133
标识
DOI:10.1002/smll.201500997
摘要
In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantages of the deep tissue penetration of enhanced magnetic resonance (MR) imaging of Gd and the high signal-to-noise ratio and high spatiotemporal resolution of fluorescence imaging in the second near-infrared window (NIR-II) of Ag2S quantum dots (QDs). Due to the abundant tumor angiogenesis and the enhanced permeability and retention effect in the tumor, a brain tumor (U87MG) in a mouse model is clearly delineated in situ with the help of the Gd assisted T1 MR imaging and the intraoperative resection of the tumor is precisely accomplished under the guidance of NIR-II fluorescence imaging of Ag2S QDs after intravenous injection of Gd-Ag2S nanoprobe. Additionally, no histologic changes are observed in the main organs of the mouse after administration of Gd-Ag2S nanoprobe for 1 month, indicating the high biocompatibility of the nanoprobe. We expect that such a novel "Detection and Operation" strategy based on Gd-Ag2S nanoprobe is promising in future clinical applications.
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