Salivary and Serum Chromogranin A and α‐Amylase in Periodontal Health and Disease

唾液 嗜铬粒蛋白A 内科学 牙周炎 医学 慢性牙周炎 内分泌学 胃肠病学 免疫组织化学
作者
Hady Haririan,Kristina Bertl,Markus Laky,Wolf‐Dieter Rausch,Michael Böettcher,M Matĕjka,Oleh Andrukhov,Xiaohui Rausch‐Fan
出处
期刊:Journal of Periodontology [Wiley]
卷期号:83 (10): 1314-1321 被引量:53
标识
DOI:10.1902/jop.2012.110604
摘要

Background: Salivary stress‐related biomarkers in connection with periodontal disease have not been extensively studied. In addition to cortisol as a well‐known marker of stress loading, chromogranin A (CgA) and α‐amylase (AA) are supposed to link the activity of the neuroendocrine system to local and systemic immune functions and to be related to periodontitis. This study aims to determine CgA and AA in saliva and serum in periodontal health and disease to assess their potential relationship to periodontitis. Methods: Patients with aggressive (AgP) (n = 24) and chronic periodontitis (CP) (n = 34) as well as healthy control (CO) (n = 30) individuals participated in this study. CgA and AA were determined in saliva and serum with enzyme‐linked immunosorbent assay and an adapted clinical amylase test; salivary cortisol was determined using mass spectrometry. Clinical parameters of periodontal disease were evaluated, and their possible correlations with stress‐related biomarkers were assessed. Results: Significantly higher CgA levels were found in the saliva of patients with AgP compared with those in patients with CP and CO individuals ( P <0.001). Salivary cortisol levels were higher in the AgP group compared with those in patients with CP ( P <0.05). No differences in serum CgA levels and salivary and serum AA activities were found among all groups. A positive correlation was revealed between salivary AA activity or salivary CgA levels and the extent of periodontitis ( P <0.05). Conclusion: The results suggest an association of CgA and cortisol levels as well as AA activity in saliva with periodontitis, especially a significant relationship of salivary CgA and cortisol to AgP.
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