医学
流行性脑脊髓膜炎
出勤
环丙沙星
家庭医学
儿科
人口
皮疹
物理疗法
内科学
脑膜炎奈瑟菌
抗生素
环境卫生
经济
微生物学
细菌
生物
遗传学
经济增长
作者
Van P. Ngo,Rachel Civen,David E. Dassey,Deborah Davenport,Laurene Mascola
出处
期刊:Biosecurity and Bioterrorism-biodefense Strategy Practice and Science
[Mary Ann Liebert]
日期:2010-03-01
卷期号:8 (1): 45-51
被引量:2
标识
DOI:10.1089/bsp.2009.0026
摘要
A point-of-dispensing clinic was held to distribute ciprofloxacin prophylaxis when 2 high school students were reported to the health department with invasive meningococcal disease. Of more than 3,100 school staff and students in attendance, 2,861 received prophylaxis. A survey was administered to students 2 weeks postclinic to better understand the motivations for clinic attendance and to quantify side effects of oral 500-mg ciprofloxacin prophylaxis. Data collected included reasons for attendance and perception of risk for acquiring meningococcal disease, rated on a 1-to-5 scale; type of contact with cases; and side effects. Of 2,888 students, 1,624 completed surveys; 1,390 took ciprofloxacin. The students rated parental influence and directives from the high school as reasons for attendance a mean of 3.97 and 3.34, respectively. The mean rating for risk of acquiring meningococcal disease was 1.49. Only 3% reported direct contact with case(s). Side effects, most commonly headache (17%) and stomachache (10%), were reported in 40% of students. Serious side effects such as rash and facial swelling were reported in <1%. In this adolescent population, few serious side effects and no joint disorders were reported after they ingested single-dose ciprofloxacin; however, many received the prophylaxis unnecessarily. Students were motivated by parents and school officials. Health departments should collaborate with schools to prepare and disseminate messages that balance the risks of unnecessary antibiotic use with those of exposure to disease.
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