A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Angewandte Chemie International EditionVolume 49, Issue 46 p. 8649-8652 Communication A Nanoparticle Size Series for In Vivo Fluorescence Imaging† Dr. Zoran Popović, Dr. Zoran Popović Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorDr. Wenhao Liu, Dr. Wenhao Liu Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorVikash P. Chauhan, Vikash P. Chauhan Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorJungmin Lee, Jungmin Lee Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorCliff Wong, Cliff Wong Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorDr. Andrew B. Greytak, Dr. Andrew B. Greytak Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorNumpon Insin, Numpon Insin Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorProf. Dr. Daniel G. Nocera, Prof. Dr. Daniel G. Nocera Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorProf. Dr. Dai Fukumura, Prof. Dr. Dai Fukumura Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorProf. Dr. Rakesh K. Jain, Prof. Dr. Rakesh K. Jain Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorProf. Dr. Moungi G. Bawendi, Prof. Dr. Moungi G. Bawendi [email protected] Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this author Dr. Zoran Popović, Dr. Zoran Popović Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorDr. Wenhao Liu, Dr. Wenhao Liu Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorVikash P. Chauhan, Vikash P. Chauhan Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorJungmin Lee, Jungmin Lee Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorCliff Wong, Cliff Wong Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorDr. Andrew B. Greytak, Dr. Andrew B. Greytak Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorNumpon Insin, Numpon Insin Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorProf. Dr. Daniel G. Nocera, Prof. Dr. Daniel G. Nocera Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this authorProf. Dr. Dai Fukumura, Prof. Dr. Dai Fukumura Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorProf. Dr. Rakesh K. Jain, Prof. Dr. Rakesh K. Jain Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston MA (USA)Search for more papers by this authorProf. Dr. Moungi G. Bawendi, Prof. Dr. Moungi G. Bawendi [email protected] Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge MA 02139-4307 (USA), Fax: (+1) 617-452-2708Search for more papers by this author First published: 30 September 2010 https://doi.org/10.1002/anie.201003142Citations: 257 † This research was supported by the U.S. National Cancer Institute grants R01-CA126642 (R.K.J., D.F., M.G.B., and D.G.N.), R01-CA085140, R01-CA115767 (R.K.J.), P01-CA080124 (R.K.J. and D.F.), R01-CA096915 (D.F.); by the MIT-Harvard NIH Center for Cancer Nanotechnology Excellence (1U54-CA119349) (M.G.B.); by the MIT DCIF (CHE-980806, DBI-9729592); by the ISN (W911NF-07-D-0004) (M.G.B and D.G.N); by the NSF-MRSEC program (DMR-0117795) via the use of its shared user facilities; and by the NSF-CRS (CHE-0714189). W.L. was supported by a NSF Graduate Research Fellowship. A.B.G. was a Novartis Fellow of the Life Sciences Research Foundation. We would like to thank S. Geyer for valuable help with quantum yield measurements and to J. Cui for the help with FCS measurements. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract A nanoparticle toolset was created within the size limits of 10–150 nm for probing size-dependent nanoparticle distribution in solid tumors. By using multiphoton intravital microscopy, the particles were tracked both spatially and temporally in the same tumor grown in a transparent window model. Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201003142_sm_miscellaneous_information.pdf591.7 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1R. K. Jain, Adv. Drug Delivery Rev. 2001, 46, 149. 2A. E. Nel, L. Madler, D. Velegol, T. Xia, E. M. Hoek, P. Somasundaran, F. Klaessig, V. Castranova, M. Thompson, Nat. Mater. 2009, 8, 543. 3S. D. Perrault, C. Walkey, T. Jennings, H. C. Fischer, W. C. W. Chan, Nano Lett. 2009, 9, 1909. 4S. K. Hobbs, W. L. Monsky, F. Yuan, W. G. Roberts, L. Griffith, V. P. Torchilin, R. K. Jain, Proc. Natl. Acad. Sci. 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