对映选择合成
电泳剂
立体中心
催化作用
试剂
化学
金鸡纳
产量(工程)
有机化学
组合化学
材料科学
冶金
作者
Teerawut Bootwicha,Xiangqian Liu,Roman Pluta,Iuliana Atodiresei,Magnus Rueping
标识
DOI:10.1002/anie.201304957
摘要
Cinchona alkaloid catalysts in combination with air- and moisture-stable N-trifluoromethylthiophthalimide as electrophilic SCF3 source enabled the catalytic enantioselective trifluoromethylsulfenylation. Thus, a series of α-SCF3 esters that bear a quaternary carbon stereogenic center were obtained with excellent yield and enantioselectivity. Moreover, the products can be readily converted into valuable α-SCF3 β-hydroxyesters.
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