氯氮平
不利影响
混乱
医学
精神分裂症(面向对象编程)
临床试验
内科学
精神科
心理学
精神分析
作者
W.W. Fleischhacker,Martina Hummer,Martin Kurz,I. Kurzthaler,J.A. Lieberman,Simcha Pollack,Allan Z. Safferman,John M. Kane
出处
期刊:PubMed
日期:1994-09-01
卷期号:55 Suppl B: 78-81
被引量:65
摘要
The report (1) provides an overview of clozapine doses used in trials conducted in Europe and the United States, (2) compares data on efficacy, and (3) compares side effects of clozapine from recent European and U.S. investigations. The reviewed European trials used a mean dose of 283.7 mg/day, while the mean dose in the U.S. studies was 444 mg/day. Even though the mean doses used in the United States are considerably higher than those used in Europe, the response rates for the two continents are strikingly similar. The main differences in a comparison of two samples evaluated in New York and Innsbruck were found in the prevalence of seizures (Innsbruck, 0%; United States, 7.1%) and confusion (Innsbruck, 0%; United States, 14%). Excitement was less prevalent in the U.S. study. The data presented appear to suggest that a lower dose of clozapine may be as effective as a higher dose in the management of treatment-resistant schizophrenic patients and may cause fewer side effects.
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