磁刺激
前额叶皮质
听力学
脑电图
心理学
电生理学
深部经颅磁刺激
注意缺陷多动障碍
神经科学
刺激
认知
医学
精神科
作者
Uri Alyagon,Hadar Shalev,Hamutal Shachar Avi Lazarovich,Dror Cohen,Abraham Zangen
标识
DOI:10.1016/j.brs.2015.01.317
摘要
Despite its high prevalence, the only empirically validated treatment for attention deficit/hyperactivity disorder (ADHD) is chronic administration of psychostimulants, which is not tolerable by all patients. Deep transcranial magnetic stimulation (dTMS) using special coil designs for targeting neural networks associated with various neuropsychiatric disorders, may become a potential alternative for such patients. In the current randomized, sham-controlled study, adult ADHD patients (n=30) received 15 daily sessions of high-frequency repetitive TMS directed to the right prefrontal cortex (rPFC), using either deep, standard figure-8, or a sham coil. ADHD symptoms and cognitive alterations were assessed using standard questionnaires and performance computerized tests. In addition, the stop signal task (SST) combined with EEG measures was used to asses behavioural inhibition and evoked response potentials (ERPs). Finally, EEG responses to single and paired TMS pulses over the rPFC were measured before and after treatments. An additional comparison group of healthy subjects (n=39) was evaluated without receiving TMS treatment.
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