生物
转移
癌症
癌症研究
谱系(遗传)
癌细胞
基因
表型
细胞
癌症干细胞
肿瘤微环境
细胞生物学
细胞培养
细胞迁移
医学
癌症转移
作者
Jeffrey J. Quinn,Matthew G. Jones,Ross A. Okimoto,Shigeki Nanjo,Michelle Chan,Nir Yosef,Trever G. Bivona,Jonathan S. Weissman
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-02-26
卷期号:371 (6532)
被引量:73
标识
DOI:10.1126/science.abc1944
摘要
Detailed phylogenies of tumor populations can recount the history and chronology of critical events during cancer progression, such as metastatic dissemination. We applied a Cas9-based, single-cell lineage tracer to study the rates, routes, and drivers of metastasis in a lung cancer xenograft mouse model. We report deeply resolved phylogenies for tens of thousands of cancer cells traced over months of growth and dissemination. This revealed stark heterogeneity in metastatic capacity, arising from preexisting and heritable differences in gene expression. We demonstrate that these identified genes can drive invasiveness and uncovered an unanticipated suppressive role for KRT17 We also show that metastases disseminated via multidirectional tissue routes and complex seeding topologies. Overall, we demonstrate the power of tracing cancer progression at subclonal resolution and vast scale.
科研通智能强力驱动
Strongly Powered by AbleSci AI