立体中心
对映选择合成
硅
手性(物理)
硅烷化
催化作用
组合化学
铑
化学
材料科学
有机化学
物理
夸克
Nambu–Jona Lasinio模型
手征对称破缺
量子力学
作者
Shuyou Chen,Delong Mu,Pei-Lin Mai,Jie Ke,Yingzi Li,Chuan He
标识
DOI:10.1038/s41467-021-21489-6
摘要
The exploitation of chirality at silicon in asymmetric catalysis is one of the most intriguing and challenging tasks in synthetic chemistry. In particular, construction of enantioenriched mediem-sized silicon-stereogenic heterocycles is highly attractive, given the increasing demand for the synthesis of novel functional-materials-oriented silicon-bridged compounds. Here, we report a rhodium-catalyzed enantioselective construction of six- and seven-membered triorgano-substituted silicon-stereogenic heterocycles. This process undergoes a direct dehydrogenative C-H silylation, giving access to a wide range of triorgano-substituted silicon-stereogenic heterocycles in good to excellent yields and enantioselectivities, that significantly enlarge the chemical space of the silicon-centered chiral molecules. Further elaboration of the chiral monohydrosilane product delivers various corresponding tetraorgano-substituted silicon-stereogenic heterocycles without the loss of enantiopurity. These silicon-bridged heterocycles exhibit bright blue fluorescence, which would have potential application prospects in organic optoelectronic materials.
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