生物
神经递质
神经递质受体
受体
神经科学
血管生成
神经递质药
肿瘤微环境
癌症
癌细胞
癌症研究
细胞生物学
免疫系统
癌变
中枢神经系统
免疫学
生物化学
遗传学
作者
Shu‐Heng Jiang,Li-Peng Hu,Xu Wang,Jun Li,Zhigang Zhang
出处
期刊:Oncogene
[Springer Nature]
日期:2019-09-16
卷期号:39 (3): 503-515
被引量:146
标识
DOI:10.1038/s41388-019-1006-0
摘要
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the stimulatory or inhibitory neuronal functions through binding to their respective receptors. In the past decades, many novel discoveries come to light elucidating the regulatory roles of neurotransmitters in the physiological and pathological functions of tissues and organs. Notably, emerging data suggest that cancer cells take advantage of the neurotransmitters-initiated signaling pathway to activate uncontrolled proliferation and dissemination. In addition, neurotransmitters can affect immune cells and endothelial cells in the tumor microenvironment to promote tumor progression. Therefore, a better understanding of the mechanisms underlying neurotransmitter function in tumorigenesis, angiogenesis, and inflammation is expected to enable the development of the next generation of antitumor therapies. Here, we summarize the recent important studies on the different neurotransmitters, their respective receptors, target cells, as well as pro/antitumor activity of specific neurotransmitter/receptor axis in cancers and provide perspectives and insights regarding the rationales and strategies of targeting neurotransmitter system to cancer treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI