The aim of this manuscript is to tackle the tracking problem for uncertain semi-Markov systems. More precisely, the mode-dependent event-triggering communication approach is introduced for networked controller design procedure, which can considerably increase the signal transmission efficiency. Based on the Lyapunov–Krasovski method, mode-dependent sufficient conditions are derived and the tracking errors could achieve the asymptotic mean-square stability, and mode-dependent controllers could be further calculated by convex optimization. A numerical simulation with application to vertical take-off and landing helicopter would be performed for verifying the availability and usefulness.