Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Abstract The enantioseparation of chiral drugs via CE was first investigated using β ‐CD as chiral additive and deep eutectic solvents (DESs) as auxiliary additive. The results showed that improved separation of tested chiral drugs was obtained in the presence of DESs and β ‐CD compared to the single β ‐CD separation system. With the optimized condition, resolutions of DESs applied β ‐CD separation system for rac ‐Zopiclone, rac ‐Salbutamol, and rac ‐Amlodipine increased 3–4.2 times as single β ‐CD separation system. The resolutions reached 4.74, 6.37, and 9.67, respectively. The results demonstrate that DESs are viable additives to CD system in CE for the separation of the chiral drugs.