树枝状大分子
药品
药物输送
结合
聚合物
纳米技术
免疫原性
聚乙二醇
医学
药理学
智能聚合物
毒品携带者
材料科学
化学
组合化学
有机化学
免疫学
数学分析
数学
免疫系统
作者
Iriny Ekladious,Yolonda L. Colson,Mark W. Grinstaff
标识
DOI:10.1038/s41573-018-0005-0
摘要
Polymer-drug conjugates have long been a mainstay of the drug delivery field, with several conjugates successfully translated into clinical practice. The conjugation of therapeutic agents to polymeric carriers, such as polyethylene glycol, offers several advantages, including improved drug solubilization, prolonged circulation, reduced immunogenicity, controlled release and enhanced safety. In this Review, we discuss the rational design, physicochemical characteristics and recent advances in the development of different classes of polymer-drug conjugates, including polymer-protein and polymer-small-molecule drug conjugates, dendrimers, polymer nanoparticles and multifunctional systems. Current obstacles hampering the clinical translation of polymer-drug conjugate therapeutics and future prospects are also presented.
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