Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis

Novel di-substituted pyrimidinyl C-nucleosides have been synthesised using a flexible synthetic methodology. This methodology conveniently allows the synthesis of alpha and beta nucleosides, both of which are of biological interest. Reactive acetylenic ketones, derived from 2-deoxyribose, can be reacted with substituted amidines to give new families of C-nucleoside natural product analogues.