生物
家禽
血清型
转录组
病毒学
医学微生物学
动物
遗传学
生态学
基因
基因表达
作者
Guangcai Ren,Han Wang,Miaorong Huang,Yuanyuan Yan,Liu Fan,Ruiai Chen
出处
期刊:Virus Genes
[Springer Nature]
日期:2019-07-01
卷期号:55 (5): 619-629
被引量:9
标识
DOI:10.1007/s11262-019-01676-w
摘要
Fowl adenovirus serotype 4 (FAdV-4) is a causative agent of inclusion body hepatitis and hydropericardium–hepatitis syndrome. These diseases cause considerable economic losses in the global poultry industry and are significant stressors for infected chickens. However, the molecular mechanisms of FAdV-4 pathogenesis are poorly understood. In the present study, we identified differentially expressed genes from the livers of FAdV-4-infected chickens using RNA-seq at 7, 14 and 21 days after FAdV-4 infection. We identified 2395 differentially expressed genes at the three time points. These genes were enriched in variety of biological processes and pathways including PPAR and Notch signaling, cytokine–cytokine receptor interactions and Toll-like receptor signaling pathways. The transcriptional data were validated by quantitative real-time PCR. Our results will assist in the understanding of the molecular pathogenesis of FAdV-4 infection and for developing novel antiviral therapies.
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