Tenascin公司
细胞外基质
纤维连接蛋白
病理
免疫染色
医学
硬化性苔藓
基底膜
弹性蛋白
层粘连蛋白
免疫组织化学
免疫学
生物
细胞生物学
作者
Flávia Caló de Aquino Xavier,Alisio Alves Prates,Clarissa Araújo Silva Gurgel,Túlio Geraldo de Souza e Souza,Rodrigo Guimarães Andrade,Eduardo Antônio Gonçalves Ramos,Luciana Maria Pedreira Ramalho,Jean Nunes dos Santos
摘要
Lichen sclerosus (LS) is a mucocutaneous disease with uncommon oral involvement. The etiology is not yet well understood, but LS has been associated with autoimmune, genetic, and immunological factors. We report a 47-year-old man with LS that exhibited an asymptomatic white plaque with red patches on the maxillary alveolar mucosa extending to the labial mucosa. He had no other skin disease. Positive immunostaining for tenascin and scarcity of fibronectin suggested extracellular matrix reorganization. Elastin immunostaining indicated a reduction of elastic fibers. Immunoexpression of collagen IV in blood vessels and its absence in the epithelial basement membrane, together with diffuse MMP-9 immunoexpression, suggested altered proteolytic activity. Mast cell staining bordering areas of sclerosis indicated a possible role in the synthesis of collagen. IgG4 positivity in plasma cells suggested a role in the fibrogenesis. This is an unusual presentation of oral LS and we discuss immunohistochemical findings regarding cellular and extracellular matrix components.
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