生物
HLA-B27
人类白细胞抗原
细胞毒性T细胞
免疫学
先天免疫系统
细胞生物学
免疫系统
内质网
抗原
抗原呈递
T细胞
遗传学
体外
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2015-03-21
卷期号:33 (1): 29-48
被引量:182
标识
DOI:10.1146/annurev-immunol-032414-112110
摘要
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides to cytotoxic T cells. Thus, HLA-B27-restricted immune responses to self-antigens, or arthritogenic peptides, might drive immunopathology. B27 can also “behave badly,” misfolding during assembly and leading to endoplasmic reticulum stress and autophagy responses. β 2 m-free B27 heavy chain structures including homodimers (B27 2 ) can also be expressed at the cell surface following endosomal recycling of cell surface heterotrimers. Cell surface free heavy chains and B27 2 bind to innate immune receptors on T, NK, and myeloid cells with proinflammatory effects. This review describes the natural function of HLA-B27, its disease associations, and the current theories as to its pathogenic role.
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