程序性细胞死亡
化学
特罗洛克
细胞
细胞损伤
谷氨酸受体
氧化应激
细胞损伤
海马结构
细胞生物学
药理学
生物化学
细胞凋亡
生物
神经科学
受体
抗氧化能力
作者
Hiroyuki Mizuno,Chisato Kubota,Yuta Takigawa,Ryosuke Shintoku,Naokatsu Kannari,Takako Muraoka,Hideru Obinata,Yuhei Yoshimoto,Masato Kanazawa,Ichiro Koshiishi,Seiji Torii
摘要
Summary Ferroptosis, a type of oxidative stress cell death, has been implicated in cell injury in several diseases, and treatments with specific inhibitors have been shown to protect cells and tissues. Here we demonstrated that a treatment with the nitroxide radical, 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), prevented the ferroptotic cell death in an airborne manner. Other TEMPO derivatives and lipophilic antioxidants, such as Trolox and ferrostatin-1, also prevented cell death induced by erastin and RSL3; however, only TEMPO exhibited inhibitory activity from a physically distant location. TEMPO vaporized without decomposing and then dissolved again into a nearby water solution. Volatilized TEMPO inhibited glutamate-induced cell death in mouse hippocampal cell lines and also reduced neuronal cell death in a mouse ischemia model. These results suggest that TEMPO is a unique cell protective agent that acts in a volatility-mediated manner.
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