DESIGN OF EXPERIMENTS FOR PREPARATION OF POLYVINYL ALCOHOL–BASED OPTIMIZED FILMS FOR NICOTINE TRANSDERMAL DELIVERY

耐折性 聚乙烯醇 肿胀 的 透皮 材料科学 含水量 尼古丁 复合材料 聚合物 化学工程 内科学 医学 岩土工程 药理学 乙基纤维素 工程类
作者
Chaowalit Monton,Watcharapong Thinchalong,Kritanon Assawawongsawat,Jessada Prasomkij,Wiwat Pichayakorn,Jirapornchai Suksaeree
出处
期刊:Xinan Jiaotong Daxue Xuebao 卷期号:57 (2): 97-112
标识
DOI:10.35741/issn.0258-2724.57.2.9
摘要

Optimized polyvinyl alcohol (PVA)-based films were prepared by blending with other excipients: deproteinized natural rubber, glycerin, and poloxamer 407. The properties of the developed optimized PVA-based film: thickness, weight variable, folding endurance, swelling ratio, and moisture content, were predicted by the Design-Expert® program. The thickness and weight variables were not found to be significantly different, but folding endurance, swelling ratio, and moisture content had significant differences. The predicted mathematical models for dependent variables were quadratic, linear, and special cubic. The linear relationships of the model conditions for optimized PVA-based films were 0.5099–0.8521 within a 95% confidence interval. The selected optimized PVA-based film was evaluated for all parameters again. The thickness, weight variable, folding endurance, swelling ratio, and moisture content were 0.209 ± 0.025 mm, 27.660 ± 3.446 mg/cm2, 1646.667 ± 45.092 times, 100.575 ± 17.121%, and 5.337 ± 0.319%, respectively. The obtained optimal formulation was then mixed with nicotine drug, and subsequently applied for transdermal delivery systems. The nicotine could be released as 1.60 ± 0.30 mg/cm2 from the film, in accordance with Higuchi’s model (R2 = 0.9701). The constant rate for nicotine release was 0.373 ± 0.049 mg/ Thus, it was concluded that the film was an effective polymer for controlling the nicotine release behavior.
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