DU145型
癌症
靶向治疗
癌症研究
光热治疗
甘露糖
纳米技术
材料科学
肺癌
癌细胞
化学
生物化学
生物
医学
肿瘤科
LNCaP公司
内科学
作者
Chang‐Hee Whang,Jungwoo Hong,Dohyeon Kim,Hong Ryu,Wonsik Jung,Youngju Son,Hyeongseop Keum,Jinjoo Kim,Hocheol Shin,Eugene Moon,Ilkoo Noh,Hee‐Seung Lee,Sangyong Jon
标识
DOI:10.1002/adma.202203993
摘要
Cancer-targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx-mimicking nanoparticles as a platform to enable screening and identification of cancer-targeting nanomedicines is reported. Specifically, a library of 31 artificial glycopolymers composed of either homogeneous or heterogeneous display of five different sugar moieties (β-glucose, β-galactose, α-mannose, β-N-acetyl glucosamine, and β-N-acetyl galactosamine) is converted to a library of glyconanoparticles (GlyNPs). GlyNPs optimal for targeting CT26, DU145, A549, and PC3 tumors are systematically screened and identified. The cypate-conjugated GlyNP displaying α-mannose and β-N-acetyl glucosamine show selective targeting and potent photothermal therapeutic efficacy against A549 human lung tumors. The docetaxel-contained GlyNP displaying β-glucose, β-galactose, and α-mannose demonstrate targeted chemotherapy against DU145 human prostate tumors. The results presented herein collectively demonstrate that the GlyNP library is a versatile platform enabling the identification of cancer-targeting glyconanoparticles and suggest its potential applicability for targeting various diseased cells beyond cancer.
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