太赫兹辐射
DNA折纸
DNA
纳米技术
氢键
光电子学
材料科学
化学
分子
生物化学
有机化学
作者
Chao Zhang,Ye Yuan,Kaijie Wu,Yue Wang,Shitai Zhu,Jiye Shi,Lihua Wang,Qian Li,Xiaolei Zuo,Chunhai Fan,Chao Chang,Jiang Li
出处
期刊:Nano Letters
[American Chemical Society]
日期:2021-12-30
卷期号:22 (1): 468-475
被引量:47
标识
DOI:10.1021/acs.nanolett.1c04369
摘要
Terahertz (THz) waves show nontrivial interactions with living systems, but the underlying molecular mechanisms have yet to be explored. Here, we employ DNA origami as a model system to study the interactions between THz waves and DNA structures. We find that a 3-min THz illumination (35.2 THz) can drive the unwinding of DNA duplexes at ∼10 °C below their melting point. Computational study reveals that the THz wave can resonate with the vibration of DNA bases, provoking the hydrogen bond breaking. The cooperation of thermal and nonthermal effects allows the unfolding of undesired secondary structures and the THz illumination can generate diverse DNA origami assemblies with the yield (>80%) ∼ 4-fold higher than that by the contact heating at similar temperatures. We also demonstrate the in situ assembly of DNA origami in cell lysate. This method enables remotely controllable assembly of intact biomacromolecules, providing new insight into the bioeffects of THz waves.
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