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Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

医学 鹿特丹研究 神经纤维层 眼科 置信区间 流行病学 屈光度 眼压 人口 优势比 高眼压 冲程(发动机) 队列研究 视网膜 内科学 视力 工程类 环境卫生 机械工程
作者
Monique M.B. Breteler,Matthias M. Mauschitz,Pieter W. M. Bonnemaijer,Kersten Diers,Franziska G. Rauscher,Tobias Elze,Christoph Engel,Markus Loeffler,Johanna M. Colijn,M. Arfan Ikram,Yurii S. Aulchenko,Katie Williams,Christopher J. Hammond,Catherine Creuzot‐Garcher,José‐Alain Sahel,Rufino Silva,Sandrina Nunes,Cécile Delcourt,Audrey Cougnard‐Grégoire,Frank G. Holz,Caroline C. W. Klaver,Monique M.B. Breteler,Robert P. Finger,Niyazi Acar,Eleftherios Anastosopoulos,Augusto Azuara‐Blanco,Tos T. J. M. Berendschot,Arthur A. Bergen,Geir Bertelsen,Christine Binquet,Alan C. Bird,Martin Bobák,Morten B. Larsen,Camiel J. F. Boon,Rupert Bourne,Lionel Brétillon,Rebecca Broe,Gabriëlle H.S. Buitendijk,Maria Luz Cachulo,Vittorio Capuano,Isabelle Carrière,Usha Chakravarthy,Michel Michaelides,Petrus Chang,Johanna M. Colijn,Angela J. Cree,Phillippa Cumberland,José Cunha‐Vaz,Vincent Daïen,Eiko de Jong,Gábor Deák,Marie‐Noëlle Delyfer,Anneke Den Hollander,Martha Dietzel,Maja Gran Erke,Pedro Faria,Cláudia Farinha,Sascha Fauser,Astrid Fletcher,Paul J. Foster,Panayiota Founti,Theo G. M. F. Gorgels,Jakob Grauslund,Franz H. Grus,Hans‐Werner Hense,Manuel M. Hermann,René Höhn,Ruth Hogg,Carel B. Hoyng,Nomdo M. Jansonius,Sarah Janssen,Eveline Kersten,Anthony P. Khawaja,Caroline C. W. Klaver,Jean‐François Korobelnik,Julia Lamparter,Mélanie Le Goff,Yara Lechanteur,Terho Lehtimäki,Irene Leung,Andrew Lotery,Magda Meester,Bénédicte Merle,Verena Meyer zu Westrup,Edoardo Midena,Stefania Miotto,Paul J. Foster,Sadek Mohan-Saïd,Michael Mueller,Alyson Muldrew,Joaquim Murta,Stefan Nickels,Christopher G. Owen,Tünde Pető,Norbert Pfeiffer,Stefano Piermarocchi,Elena Prokofyeva,Jugnoo S. Rahi,Olli T. Raitakari,Luísa Ribeiro,Marie-Bénédicte Rougier,Alicja R. Rudnicka,José‐Alain Sahel,Aggeliki Salonikiou,Clarisa Sánchez,Steffen Schmitz‐Valckenberg,Alexander K. Schuster,Cédric Schweitzer,Tatiana Segato,Jasmin Shehata,Giuliana Silvestri,Christian Simader,Eric H. Souied,Martynas Špečkauskas,Henriët Springelkamp,Robyn J. Tapp,Fotis Topouzis,Elisa van Leeuwen,Virginie J. M. Verhoeven,Timo Verzijden,Therese von Hanno,Peter M. Wiedemann,Christian Wolfram,Jennifer Yip,Jennyfer Zerbib
出处
期刊:Ophthalmology [Elsevier BV]
卷期号:125 (10): 1526-1536 被引量:65
标识
DOI:10.1016/j.ophtha.2018.03.026
摘要

Purpose To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Design Cross-sectional meta-analysis. Participants A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. Methods We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Main Outcome Measures Determinants of pRNFLT. Results Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). Conclusions In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities. To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. Cross-sectional meta-analysis. A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3–82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. Determinants of pRNFLT. Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = –0.38 μm/year; 95% confidence interval [CI], –0.57 to –0.18), higher intraocular pressure (IOP) (β = –0.36 μm/mmHg; 95% CI, –0.56 to –0.15), visual impairment (β = –5.50 μm; 95% CI, –9.37 to –1.64), and history of systemic hypertension (β = –0.54 μm; 95% CI, –1.01 to –0.07) and stroke (β = –1.94 μm; 95% CI, –3.17 to –0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = –3.11 μm; 95% CI, –6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19–1.59) and smoking (β = 1.53 μm; 95% CI, 1.00–2.06 for current smokers compared with never-smokers). In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.
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