T177. Dynamic Temporal Inflexibility of the Frontoparietal Network Predicts Depression Severity and Treatment Response in Internalizing Psychopathologies

Internalizing psychopathologies (IPs), such as anxiety disorders and depression, are highly comorbid and share neurobiological mechanisms. In IPs, the frontoparietal network (FPN) has been heavily implicated, and FPN regions are common targets of TMS studies. However, how dynamic temporal inflexibility of the FPN contributes to IP symptoms and influences cognitive behavioral therapy (CBT) remains poorly understood. Here we address these questions in two large fMRI resting-state datasets involving treatment-seeking patients with IPs.